Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.
Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.
Auteurs : Yulong Gao [Australie] ; Fernando Souza-Fonseca-Guimaraes [Australie] ; Tobias Bald [Australie] ; Susanna S. Ng [Australie] ; Arabella Young [Australie] ; Shin Foong Ngiow [Australie] ; Jai Rautela [Australie] ; Jasmin Straube [Australie] ; Nic Waddell [Australie] ; Stephen J. Blake [Australie] ; Juming Yan [Australie] ; Laurent Bartholin [France] ; Jason S. Lee [Australie] ; Eric Vivier [France] ; Kazuyoshi Takeda [Japon] ; Meriem Messaoudene [France] ; Laurence Zitvogel [France] ; Michele W L. Teng [Australie] ; Gabrielle T. Belz [Australie] ; Christian R. Engwerda [Australie] ; Nicholas D. Huntington [Australie] ; Kyohei Nakamura [Australie] ; Michael Hölzel [Allemagne] ; Mark J. Smyth [Australie]Source :
- Nature immunology [ 1529-2916 ] ; 2017.
Descripteurs français
- KwdFr :
- Analyse de profil d'expression de gènes, Analyse de séquence d'ARN, Animaux, Cellules tueuses naturelles (cytologie), Cellules tueuses naturelles (immunologie), Cytométrie en flux, Facteur de croissance transformant bêta (immunologie), Fibrosarcome (immunologie), Humains, Immunité innée (immunologie), Lignée cellulaire tumorale, Lymphocytes (cytologie), Lymphocytes (immunologie), Reprogrammation cellulaire (immunologie), Souris, Test ELISA, Transduction du signal, Tumeurs expérimentales (immunologie), Tumeurs gastro-intestinales (immunologie), Tumeurs stromales gastro-intestinales (immunologie), Échappement de la tumeur à la surveillance immunitaire (immunologie), Études cas-témoins.
- MESH :
- cytologie : Cellules tueuses naturelles, Lymphocytes.
- immunologie : Cellules tueuses naturelles, Facteur de croissance transformant bêta, Fibrosarcome, Immunité innée, Lymphocytes, Reprogrammation cellulaire, Tumeurs expérimentales, Tumeurs gastro-intestinales, Tumeurs stromales gastro-intestinales, Échappement de la tumeur à la surveillance immunitaire.
- Analyse de profil d'expression de gènes, Analyse de séquence d'ARN, Animaux, Cytométrie en flux, Humains, Lignée cellulaire tumorale, Souris, Test ELISA, Transduction du signal, Études cas-témoins.
English descriptors
- KwdEn :
- Animals, Case-Control Studies, Cell Line, Tumor, Cellular Reprogramming (immunology), Enzyme-Linked Immunosorbent Assay, Fibrosarcoma (immunology), Flow Cytometry, Gastrointestinal Neoplasms (immunology), Gastrointestinal Stromal Tumors (immunology), Gene Expression Profiling, Humans, Immunity, Innate (immunology), Killer Cells, Natural (cytology), Killer Cells, Natural (immunology), Lymphocytes (cytology), Lymphocytes (immunology), Mice, Neoplasms, Experimental (immunology), Sequence Analysis, RNA, Signal Transduction, Transforming Growth Factor beta (immunology), Tumor Escape (immunology).
- MESH :
- chemical , immunology : Transforming Growth Factor beta.
- cytology : Killer Cells, Natural, Lymphocytes.
- immunology : Cellular Reprogramming, Fibrosarcoma, Gastrointestinal Neoplasms, Gastrointestinal Stromal Tumors, Immunity, Innate, Killer Cells, Natural, Lymphocytes, Neoplasms, Experimental, Tumor Escape.
- Animals, Case-Control Studies, Cell Line, Tumor, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Gene Expression Profiling, Humans, Mice, Sequence Analysis, RNA, Signal Transduction.
Abstract
Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a(-)CD49b(+)Eomes(+)) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a(+)CD49b(+)Eomes(+)) populations and ILC1 (CD49a(+)CD49b(-)Eomes(int)) populations in the tumor microenvironment. Strikingly, intILC1s and ILC1s were unable to control local tumor growth and metastasis, whereas NK cells favored tumor immunosurveillance. Experiments with an antibody that neutralizes the cytokine TNF suggested that escape from the innate immune system was partially mediated by TNF-producing ILC1s. Our findings provide new insight into the plasticity of group 1 ILCs in the tumor microenvironment and suggest that the TGF-β-driven conversion of NK cells into ILC1s is a previously unknown mechanism by which tumors escape surveillance by the innate immune system.
DOI: 10.1038/ni.3800
PubMed: 28759001
Affiliations:
- Allemagne, Australie, France, Japon
- Auvergne-Rhône-Alpes, District de Cologne, Provence-Alpes-Côte d'Azur, Rhénanie-du-Nord-Westphalie, Rhône-Alpes, Région de Kantō, Victoria (État)
- Bonn, Lyon, Marseille, Melbourne, Tokyo
- Université Claude Bernard Lyon 1, Université d'Aix-Marseille, Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000626
- to stream PubMed, to step Curation: 000624
- to stream PubMed, to step Checkpoint: 000624
- to stream Ncbi, to step Merge: 004C17
- to stream Ncbi, to step Curation: 004C17
- to stream Ncbi, to step Checkpoint: 004C17
- to stream Main, to step Merge: 000116
- to stream Main, to step Curation: 000121
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.</title><author><name sortKey="Gao, Yulong" sort="Gao, Yulong" uniqKey="Gao Y" first="Yulong" last="Gao">Yulong Gao</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Bald, Tobias" sort="Bald, Tobias" uniqKey="Bald T" first="Tobias" last="Bald">Tobias Bald</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Susanna S" sort="Ng, Susanna S" uniqKey="Ng S" first="Susanna S" last="Ng">Susanna S. Ng</name><affiliation wicri:level="1"><nlm:affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Young, Arabella" sort="Young, Arabella" uniqKey="Young A" first="Arabella" last="Young">Arabella Young</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Ngiow, Shin Foong" sort="Ngiow, Shin Foong" uniqKey="Ngiow S" first="Shin Foong" last="Ngiow">Shin Foong Ngiow</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Rautela, Jai" sort="Rautela, Jai" uniqKey="Rautela J" first="Jai" last="Rautela">Jai Rautela</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Straube, Jasmin" sort="Straube, Jasmin" uniqKey="Straube J" first="Jasmin" last="Straube">Jasmin Straube</name><affiliation wicri:level="1"><nlm:affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Waddell, Nic" sort="Waddell, Nic" uniqKey="Waddell N" first="Nic" last="Waddell">Nic Waddell</name><affiliation wicri:level="1"><nlm:affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Blake, Stephen J" sort="Blake, Stephen J" uniqKey="Blake S" first="Stephen J" last="Blake">Stephen J. Blake</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Juming" sort="Yan, Juming" uniqKey="Yan J" first="Juming" last="Yan">Juming Yan</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, The University of Queensland, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Bartholin, Laurent" sort="Bartholin, Laurent" uniqKey="Bartholin L" first="Laurent" last="Bartholin">Laurent Bartholin</name><affiliation wicri:level="4"><nlm:affiliation>Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement><settlement type="city">Lyon</settlement></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation wicri:level="1"><nlm:affiliation>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><affiliation wicri:level="4"><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Takeda, Kazuyoshi" sort="Takeda, Kazuyoshi" uniqKey="Takeda K" first="Kazuyoshi" last="Takeda">Kazuyoshi Takeda</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cell Biology, Biomedical Research Center and Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cell Biology, Biomedical Research Center and Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Messaoudene, Meriem" sort="Messaoudene, Meriem" uniqKey="Messaoudene M" first="Meriem" last="Messaoudene">Meriem Messaoudene</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1015, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Teng, Michele W L" sort="Teng, Michele W L" uniqKey="Teng M" first="Michele W L" last="Teng">Michele W L. Teng</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, The University of Queensland, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Engwerda, Christian R" sort="Engwerda, Christian R" uniqKey="Engwerda C" first="Christian R" last="Engwerda">Christian R. Engwerda</name><affiliation wicri:level="1"><nlm:affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Nakamura, Kyohei" sort="Nakamura, Kyohei" uniqKey="Nakamura K" first="Kyohei" last="Nakamura">Kyohei Nakamura</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Holzel, Michael" sort="Holzel, Michael" uniqKey="Holzel M" first="Michael" last="Hölzel">Michael Hölzel</name><affiliation wicri:level="3"><nlm:affiliation>Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28759001</idno><idno type="pmid">28759001</idno><idno type="doi">10.1038/ni.3800</idno><idno type="wicri:Area/PubMed/Corpus">000626</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000626</idno><idno type="wicri:Area/PubMed/Curation">000624</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000624</idno><idno type="wicri:Area/PubMed/Checkpoint">000624</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000624</idno><idno type="wicri:Area/Ncbi/Merge">004C17</idno><idno type="wicri:Area/Ncbi/Curation">004C17</idno><idno type="wicri:Area/Ncbi/Checkpoint">004C17</idno><idno type="wicri:Area/Main/Merge">000116</idno><idno type="wicri:Area/Main/Curation">000121</idno><idno type="wicri:Area/Main/Exploration">000121</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.</title><author><name sortKey="Gao, Yulong" sort="Gao, Yulong" uniqKey="Gao Y" first="Yulong" last="Gao">Yulong Gao</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Bald, Tobias" sort="Bald, Tobias" uniqKey="Bald T" first="Tobias" last="Bald">Tobias Bald</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Ng, Susanna S" sort="Ng, Susanna S" uniqKey="Ng S" first="Susanna S" last="Ng">Susanna S. Ng</name><affiliation wicri:level="1"><nlm:affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Young, Arabella" sort="Young, Arabella" uniqKey="Young A" first="Arabella" last="Young">Arabella Young</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Ngiow, Shin Foong" sort="Ngiow, Shin Foong" uniqKey="Ngiow S" first="Shin Foong" last="Ngiow">Shin Foong Ngiow</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Rautela, Jai" sort="Rautela, Jai" uniqKey="Rautela J" first="Jai" last="Rautela">Jai Rautela</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Straube, Jasmin" sort="Straube, Jasmin" uniqKey="Straube J" first="Jasmin" last="Straube">Jasmin Straube</name><affiliation wicri:level="1"><nlm:affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Waddell, Nic" sort="Waddell, Nic" uniqKey="Waddell N" first="Nic" last="Waddell">Nic Waddell</name><affiliation wicri:level="1"><nlm:affiliation>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Medical Genomics, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Blake, Stephen J" sort="Blake, Stephen J" uniqKey="Blake S" first="Stephen J" last="Blake">Stephen J. Blake</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Immunoregulation and Immunotherapy, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Juming" sort="Yan, Juming" uniqKey="Yan J" first="Juming" last="Yan">Juming Yan</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, The University of Queensland, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Bartholin, Laurent" sort="Bartholin, Laurent" uniqKey="Bartholin L" first="Laurent" last="Bartholin">Laurent Bartholin</name><affiliation wicri:level="4"><nlm:affiliation>Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement><settlement type="city">Lyon</settlement></placeName><orgName type="university">Université Claude Bernard Lyon 1</orgName></affiliation></author><author><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><affiliation wicri:level="1"><nlm:affiliation>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Control of Gene Expression Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><affiliation wicri:level="4"><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, INSERM, CNRS, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Takeda, Kazuyoshi" sort="Takeda, Kazuyoshi" uniqKey="Takeda K" first="Kazuyoshi" last="Takeda">Kazuyoshi Takeda</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cell Biology, Biomedical Research Center and Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cell Biology, Biomedical Research Center and Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Messaoudene, Meriem" sort="Messaoudene, Meriem" uniqKey="Messaoudene M" first="Meriem" last="Messaoudene">Meriem Messaoudene</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U1015, Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1015, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name><affiliation wicri:level="1"><nlm:affiliation>Gustave Roussy Cancer Campus, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Teng, Michele W L" sort="Teng, Michele W L" uniqKey="Teng M" first="Michele W L" last="Teng">Michele W L. Teng</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, The University of Queensland, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine, The University of Queensland, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Engwerda, Christian R" sort="Engwerda, Christian R" uniqKey="Engwerda C" first="Christian R" last="Engwerda">Christian R. Engwerda</name><affiliation wicri:level="1"><nlm:affiliation>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Molecular Immunology Division, The Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology and The University of Melbourne, Parkville, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Nakamura, Kyohei" sort="Nakamura, Kyohei" uniqKey="Nakamura K" first="Kyohei" last="Nakamura">Kyohei Nakamura</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Holzel, Michael" sort="Holzel, Michael" uniqKey="Holzel M" first="Michael" last="Hölzel">Michael Hölzel</name><affiliation wicri:level="3"><nlm:affiliation>Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Unit for RNA Biology, Department of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation wicri:level="1"><nlm:affiliation>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature immunology</title><idno type="eISSN">1529-2916</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Case-Control Studies</term><term>Cell Line, Tumor</term><term>Cellular Reprogramming (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Fibrosarcoma (immunology)</term><term>Flow Cytometry</term><term>Gastrointestinal Neoplasms (immunology)</term><term>Gastrointestinal Stromal Tumors (immunology)</term><term>Gene Expression Profiling</term><term>Humans</term><term>Immunity, Innate (immunology)</term><term>Killer Cells, Natural (cytology)</term><term>Killer Cells, Natural (immunology)</term><term>Lymphocytes (cytology)</term><term>Lymphocytes (immunology)</term><term>Mice</term><term>Neoplasms, Experimental (immunology)</term><term>Sequence Analysis, RNA</term><term>Signal Transduction</term><term>Transforming Growth Factor beta (immunology)</term><term>Tumor Escape (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Analyse de séquence d'ARN</term><term>Animaux</term><term>Cellules tueuses naturelles (cytologie)</term><term>Cellules tueuses naturelles (immunologie)</term><term>Cytométrie en flux</term><term>Facteur de croissance transformant bêta (immunologie)</term><term>Fibrosarcome (immunologie)</term><term>Humains</term><term>Immunité innée (immunologie)</term><term>Lignée cellulaire tumorale</term><term>Lymphocytes (cytologie)</term><term>Lymphocytes (immunologie)</term><term>Reprogrammation cellulaire (immunologie)</term><term>Souris</term><term>Test ELISA</term><term>Transduction du signal</term><term>Tumeurs expérimentales (immunologie)</term><term>Tumeurs gastro-intestinales (immunologie)</term><term>Tumeurs stromales gastro-intestinales (immunologie)</term><term>Échappement de la tumeur à la surveillance immunitaire (immunologie)</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules tueuses naturelles</term><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Killer Cells, Natural</term><term>Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules tueuses naturelles</term><term>Facteur de croissance transformant bêta</term><term>Fibrosarcome</term><term>Immunité innée</term><term>Lymphocytes</term><term>Reprogrammation cellulaire</term><term>Tumeurs expérimentales</term><term>Tumeurs gastro-intestinales</term><term>Tumeurs stromales gastro-intestinales</term><term>Échappement de la tumeur à la surveillance immunitaire</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cellular Reprogramming</term><term>Fibrosarcoma</term><term>Gastrointestinal Neoplasms</term><term>Gastrointestinal Stromal Tumors</term><term>Immunity, Innate</term><term>Killer Cells, Natural</term><term>Lymphocytes</term><term>Neoplasms, Experimental</term><term>Tumor Escape</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Case-Control Studies</term><term>Cell Line, Tumor</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Flow Cytometry</term><term>Gene Expression Profiling</term><term>Humans</term><term>Mice</term><term>Sequence Analysis, RNA</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de profil d'expression de gènes</term><term>Analyse de séquence d'ARN</term><term>Animaux</term><term>Cytométrie en flux</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Souris</term><term>Test ELISA</term><term>Transduction du signal</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately evade control by natural killer (NK) cells remains incompletely defined. Using global transcriptomic and flow-cytometry analyses and genetically engineered mouse models, we identified the cytokine-TGF-β-signaling-dependent conversion of NK cells (CD49a(-)CD49b(+)Eomes(+)) into intermediate type 1 innate lymphoid cell (intILC1) (CD49a(+)CD49b(+)Eomes(+)) populations and ILC1 (CD49a(+)CD49b(-)Eomes(int)) populations in the tumor microenvironment. Strikingly, intILC1s and ILC1s were unable to control local tumor growth and metastasis, whereas NK cells favored tumor immunosurveillance. Experiments with an antibody that neutralizes the cytokine TNF suggested that escape from the innate immune system was partially mediated by TNF-producing ILC1s. Our findings provide new insight into the plasticity of group 1 ILCs in the tumor microenvironment and suggest that the TGF-β-driven conversion of NK cells into ILC1s is a previously unknown mechanism by which tumors escape surveillance by the innate immune system.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Japon</li></country><region><li>Auvergne-Rhône-Alpes</li><li>District de Cologne</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhénanie-du-Nord-Westphalie</li><li>Rhône-Alpes</li><li>Région de Kantō</li><li>Victoria (État)</li></region><settlement><li>Bonn</li><li>Lyon</li><li>Marseille</li><li>Melbourne</li><li>Tokyo</li></settlement><orgName><li>Université Claude Bernard Lyon 1</li><li>Université d'Aix-Marseille</li><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Gao, Yulong" sort="Gao, Yulong" uniqKey="Gao Y" first="Yulong" last="Gao">Yulong Gao</name></noRegion><name sortKey="Bald, Tobias" sort="Bald, Tobias" uniqKey="Bald T" first="Tobias" last="Bald">Tobias Bald</name><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name><name sortKey="Blake, Stephen J" sort="Blake, Stephen J" uniqKey="Blake S" first="Stephen J" last="Blake">Stephen J. Blake</name><name sortKey="Engwerda, Christian R" sort="Engwerda, Christian R" uniqKey="Engwerda C" first="Christian R" last="Engwerda">Christian R. Engwerda</name><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name><name sortKey="Lee, Jason S" sort="Lee, Jason S" uniqKey="Lee J" first="Jason S" last="Lee">Jason S. Lee</name><name sortKey="Nakamura, Kyohei" sort="Nakamura, Kyohei" uniqKey="Nakamura K" first="Kyohei" last="Nakamura">Kyohei Nakamura</name><name sortKey="Ng, Susanna S" sort="Ng, Susanna S" uniqKey="Ng S" first="Susanna S" last="Ng">Susanna S. Ng</name><name sortKey="Ngiow, Shin Foong" sort="Ngiow, Shin Foong" uniqKey="Ngiow S" first="Shin Foong" last="Ngiow">Shin Foong Ngiow</name><name sortKey="Rautela, Jai" sort="Rautela, Jai" uniqKey="Rautela J" first="Jai" last="Rautela">Jai Rautela</name><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><name sortKey="Souza Fonseca Guimaraes, Fernando" sort="Souza Fonseca Guimaraes, Fernando" uniqKey="Souza Fonseca Guimaraes F" first="Fernando" last="Souza-Fonseca-Guimaraes">Fernando Souza-Fonseca-Guimaraes</name><name sortKey="Straube, Jasmin" sort="Straube, Jasmin" uniqKey="Straube J" first="Jasmin" last="Straube">Jasmin Straube</name><name sortKey="Teng, Michele W L" sort="Teng, Michele W L" uniqKey="Teng M" first="Michele W L" last="Teng">Michele W L. Teng</name><name sortKey="Waddell, Nic" sort="Waddell, Nic" uniqKey="Waddell N" first="Nic" last="Waddell">Nic Waddell</name><name sortKey="Yan, Juming" sort="Yan, Juming" uniqKey="Yan J" first="Juming" last="Yan">Juming Yan</name><name sortKey="Young, Arabella" sort="Young, Arabella" uniqKey="Young A" first="Arabella" last="Young">Arabella Young</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bartholin, Laurent" sort="Bartholin, Laurent" uniqKey="Bartholin L" first="Laurent" last="Bartholin">Laurent Bartholin</name></region><name sortKey="Messaoudene, Meriem" sort="Messaoudene, Meriem" uniqKey="Messaoudene M" first="Meriem" last="Messaoudene">Meriem Messaoudene</name><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name><name sortKey="Zitvogel, Laurence" sort="Zitvogel, Laurence" uniqKey="Zitvogel L" first="Laurence" last="Zitvogel">Laurence Zitvogel</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Takeda, Kazuyoshi" sort="Takeda, Kazuyoshi" uniqKey="Takeda K" first="Kazuyoshi" last="Takeda">Kazuyoshi Takeda</name></region></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Holzel, Michael" sort="Holzel, Michael" uniqKey="Holzel M" first="Michael" last="Hölzel">Michael Hölzel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000121 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000121 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28759001
|texte= Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28759001" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |